| First Author | Yoo JK | Year | 2002 |
| Journal | J Immunol | Volume | 169 |
| Issue | 7 | Pages | 3637-43 |
| PubMed ID | 12244155 | Mgi Jnum | J:79233 |
| Mgi Id | MGI:2387534 | Doi | 10.4049/jimmunol.169.7.3637 |
| Citation | Yoo JK, et al. (2002) IL-12 Provides Proliferation and Survival Signals to Murine CD4(+) T Cells Through Phosphatidylinositol 3-Kinase/Akt Signaling Pathway. J Immunol 169(7):3637-43 |
| abstractText | IL-12 is a pleiotropic cytokine that plays an important role in innate and adaptive immunity. IL-12 induces T cell proliferation and IFN-gamma secretion from activated T cells. It was also reported that IL-12 prevents apoptosis of CD4(+) T cells. However, the signaling mechanism that regulates these IL-12-induced responses is poorly understood yet. In this study, we demonstrated that IL-12 activates phosphatidylinositol 3-kinase (PI3K)/Akt pathway in murine CD4(+) T cells, and that this signaling pathway is required for IL-12-induced T cell proliferation and antiapoptotic function, but not for IFN-gamma induction. Through PI3K/Akt pathway, IL-12 up-regulates the expression of cell cycle-related molecule such as cyclin D3, and antiapoptotic molecules such as Bcl-2 and cellular inhibitors of apoptosis proteins-2, followed by down-regulation of active caspase-3. These results suggest that PI3K/Akt pathway is critical for mediating IL-12-induced CD4(+) T cell responses such as T cell proliferation and survival. |
