| First Author | Torchia J | Year | 1997 |
| Journal | Nature | Volume | 387 |
| Issue | 6634 | Pages | 677-84 |
| PubMed ID | 9192892 | Mgi Jnum | J:42181 |
| Mgi Id | MGI:1095267 | Doi | 10.1038/42652 |
| Citation | Torchia J, et al. (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature 387(6634):677-84 |
| abstractText | The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-activator protein NCoA-1 is also specifically required for ligand-dependent activation of genes by nuclear receptors. p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways. |
