| Primary Identifier | IPR030278 | Type | Family |
| Short Name | BSEP |
| description | Bile salt export pump (BSEP) is also known as ATP-binding cassette sub-family B member 11 (ABCB11). It is a major transporter responsible for biliary bile acid secretion []. Disruption of the receptor is a risk factor for intrahepatic cholestasis of pregnancy (ICP), a liver disorder associated with increased risk of intrauterine foetal death and prematurity []. Mutations in the ABCB11 gene also cause progressive familial intrahepatic cholestasis type 2 (PFIC2), which is characterised by cholestasis, accompanied with either normal or increased serum gamma-glutamyltransferase activity [, ]. |
