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Protein Coding Gene : Akr1c6 aldo-keto reductase family 1, member C6
Primary Identifier  MGI:1933427 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  83702
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables estradiol 17-beta-dehydrogenase [NAD(P)] activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and steroid metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; liver and biliary system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4).
  • synonyms:
  • hydroxysteroid (17-beta) dehydrogenase 5,
  • hydroxysteroid 17-beta dehydrogenase 5,
  • Akr1c1,
  • aldo-keto reductase family 1, member C6,
  • aldo-keto reductase family 1, member C1,
  • 3alpha-HSD,
  • MGI:1931562,
  • MGI:1096387,
  • estradiol 17-beta-dehydrogenase (A-specific),
  • Akr1c6,
  • Hsd17b5
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