| Primary Identifier | MGI:1860493 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 54126 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables guanyl-nucleotide exchange factor activity and protein kinase binding activity. Involved in lamellipodium assembly. Acts upstream of or within hematopoietic progenitor cell differentiation and positive regulation of growth hormone secretion. Located in several cellular components, including lamellipodium; postsynapse; and storage vacuole. Is expressed in several structures, including genitourinary system; liver; nervous system; and retina. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit placental defects and complete lethality throughout fetal growth and development. Mice homozygous for a different null allele exhibit embryonic death around E8.5, double axis, and impaired anterior visceral endoderm cell migration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
