| Primary Identifier | IPR038505 | Type | Homologous_superfamily |
| Short Name | FANCF_C_sf |
| description | Fanconi anemia (FA) is a genomic instability syndrome caused by mutations in at least 13 distinct genes whose products function in a common DNA repair signaling pathway, the FA pathway. The FA pathway cooperates with other DNA repair proteins for resolving DNA interstrand cross-links during replication [].Fanconi anemia group F protein (FANCF) is a component of the FA core complex [, ]. FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway [].This entry represents the C-terminal region of the FANCF protein found in metazoa. The C-terminal domain has an helical repeat structure and is necessary for the proper assembly of the FA core complex []. |
