| Primary Identifier | IPR035485 | Type | Domain |
| Short Name | GRAF2_SH3 |
| description | GRAF2, also called Rho GTPase activating protein 10 (ARHGAP10) or PS-GAP, is a GAP with activity towards Cdc42 and RhoA []. It regulates caspase-activated p21-activated protein kinase-2 (PAK-2p34). GRAF2 interacts with PAK-2p34, leading to its stabilization and decrease of cell death []. It is highly expressed in skeletal muscle, and is involved in alpha-catenin recruitment at cell-cell junctions []. GRAF2 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, a Rho GAP domain, and a C-terminal SH3 domain. The SH3 domain of GRAF binds PKNbeta, a target of the small GTPase Rho []. This entry represents the SH3 domain of GRAF2. |
