Primary Identifier | MGI:2182141 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Npm2 |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 2 (including the ATG initiation codon), exon 3 and the splice acceptor junction of exon 4 were replaced with a Pgk-HPRT expression cassette. Homozygous mutant ovaries lacked NPM2 protein as indicated by immunohistochemistry and Western blot analysis. |