Primary Identifier | MGI:1341909 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 17087 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable lipopolysaccharide immune receptor activity. Involved in cellular response to lipopolysaccharide; positive regulation of tumor necrosis factor production; and toll-like receptor 4 signaling pathway. Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Part of lipopolysaccharide receptor complex. Is expressed in several structures, including extraembryonic component; gonad; immune system; integumental system; and nervous system. Orthologous to human LY96 (lymphocyte antigen 96). PHENOTYPE: Mice homozygous for a knock-out allele display impaired responsiveness to LPS, are resistant to LPS-induced lethal toxicity but show increased susceptibility to Salmonella typhimurium infection. [provided by MGI curators] |