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Protein Coding Gene : Bmp4 bone morphogenetic protein 4

Primary Identifier  MGI:88180 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  12159
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables heparin binding activity. Involved in several processes, including bone development; circulatory system development; and positive regulation of cell differentiation. Acts upstream of with a positive effect on positive regulation of protein localization to nucleus. Acts upstream of or within several processes, including embryonic morphogenesis; morphogenesis of a branching epithelium; and nervous system development. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Axenfeld-Rieger syndrome type 3; atrioventricular septal defect; cleft palate-lateral synechia syndrome; fibrodysplasia ossificans progressiva; and urinary system disease. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4).
PHENOTYPE: Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells. [provided by MGI curators]
  • synonyms:
  • Bmp4,
  • Bmp2b-1,
  • MGD-MRK-1596,
  • bone morphogenetic protein 2b 1,
  • MGD-MRK-1597,
  • Bmp2b,
  • Bmp-4,
  • MGD-MRK-1600,
  • MGD-MRK-1602,
  • bone morphogenetic protein 4,
  • bone morphogenetic protein 2b,
  • Bmp2b1

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

7 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

7 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For