First Author | Hara Y | Year | 1990 |
Journal | Brain Res Mol Brain Res | Volume | 8 |
Issue | 4 | Pages | 319-24 |
PubMed ID | 2176709 | Mgi Jnum | J:10931 |
Mgi Id | MGI:59374 | Doi | 10.1016/0169-328x(90)90045-f |
Citation | Hara Y, et al. (1990) Structure of mouse vasopressin and oxytocin genes. Brain Res Mol Brain Res 8(4):319-24 |
abstractText | Mouse vasopressin (VP) and oxytocin (OT) genes were isolated from a genomic library and the nucleotide sequences of the two genes were determined. The two genes have similar three exon structures and a high similarity in the part of exon 1 encoding vasopressin or oxytocin nonapeptide and in exon 2 encoding the central core of neurophysin. They are linked together in a tail to tail orientation separated by a short 3.5 kb intergenic sequence and are transcribed from opposite strands. Both genes have a single transcription initiation site downstream from a TATA-like sequence and a single polyadenylated transcript of about 760 bp for the vasopressin mRNA and about 700 bp for the oxytocin mRNA. |