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Publication : Structure of mouse vasopressin and oxytocin genes.

First Author  Hara Y Year  1990
Journal  Brain Res Mol Brain Res Volume  8
Issue  4 Pages  319-24
PubMed ID  2176709 Mgi Jnum  J:10931
Mgi Id  MGI:59374 Doi  10.1016/0169-328x(90)90045-f
Citation  Hara Y, et al. (1990) Structure of mouse vasopressin and oxytocin genes. Brain Res Mol Brain Res 8(4):319-24
abstractText  Mouse vasopressin (VP) and oxytocin (OT) genes were isolated from a genomic library and the nucleotide sequences of the two genes were determined. The two genes have similar three exon structures and a high similarity in the part of exon 1 encoding vasopressin or oxytocin nonapeptide and in exon 2 encoding the central core of neurophysin. They are linked together in a tail to tail orientation separated by a short 3.5 kb intergenic sequence and are transcribed from opposite strands. Both genes have a single transcription initiation site downstream from a TATA-like sequence and a single polyadenylated transcript of about 760 bp for the vasopressin mRNA and about 700 bp for the oxytocin mRNA.
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