| Primary Identifier | MGI:1913975 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 66725 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including Golgi organization; negative regulation of Notch signaling pathway; and protein import into nucleus. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb bud; and spinal cord. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
