| First Author | Soga T | Year | 2003 |
| Journal | Biochem Biophys Res Commun | Volume | 303 |
| Issue | 1 | Pages | 364-9 |
| PubMed ID | 12646212 | Mgi Jnum | J:82939 |
| Mgi Id | MGI:2656085 | Doi | 10.1016/s0006-291x(03)00342-5 |
| Citation | Soga T, et al. (2003) Molecular identification of nicotinic acid receptor. Biochem Biophys Res Commun 303(1):364-9 |
| abstractText | Nicotinic acid and its derivative, Acipimox, have been widely used in the treatment of hyperlipidemia. Pharmacological studies have demonstrated that they exert the beneficial effect through the activation of a Gi-protein-coupled receptor on adipocyte, which has remained elusive to date. Here we show that a novel GPCR, designated HM74b because of its high similarity to HM74, is a receptor for nicotinic acid. HM74b mRNA is found in human, murine, and rat adipose tissues. Nicotinic acid and Acipimox inhibit forskolin-stimulated intracellular cAMP accumulation in human HM74b-expressing cells and activate GTP gamma S binding in a dose-dependent manner. [3H]Nicotinic acid specifically binds to HM74b-expressing membrane and its binding is replaced by Acipimox. This finding will open a new phase of research on the physiological role of nicotinic acid and will be a clue to develop novel antihyperlipidemic drugs. |
