| First Author | Qiu Y | Year | 1995 |
| Journal | Genomics | Volume | 29 |
| Issue | 1 | Pages | 240-6 |
| PubMed ID | 8530078 | Mgi Jnum | J:28834 |
| Mgi Id | MGI:76373 | Doi | 10.1006/geno.1995.1237 |
| Citation | Qiu Y, et al. (1995) Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. Genomics 29(1):240-6 |
| abstractText | Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are orphan members of the steroid/thyroid hormone receptor superfamily. COUP-TF homologues have been cloned in many species, from Drosophila to human. The protein sequences of COUP-TFs are highly homologous across species, suggesting functional conservation. Two COUP-TF genes have been cloned from human, and their genomic organizations have been characterized. To determine whether the genomic organization is conserved between human and mouse, we isolated two mouse COUP-TF genes (I and II) and characterized their genomic structures. Both genes have relatively simple structures that are similar to those of their human counterparts. In addition, we mapped mouse COUP-TF I to the distal region of chromosome 13 and COUP-TF II to the central region of chromosome 7. Furthermore, we mapped human COUP-TF I to 5q14 of chromosome 5 and COUP-TF II to 15q26 of chromosome 15. The results demonstrate that COUP-TF genes are located in chromosomal regions that are syntenic between mouse and human. |
