| First Author | Leder S | Year | 1999 |
| Journal | Biochem Biophys Res Commun | Volume | 254 |
| Issue | 2 | Pages | 474-9 |
| PubMed ID | 9918863 | Mgi Jnum | J:52193 |
| Mgi Id | MGI:1328624 | Doi | 10.1006/bbrc.1998.9967 |
| Citation | Leder S, et al. (1999) Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. Biochem Biophys Res Commun 254(2):474-9 |
| abstractText | The DYRK1A gene on human chromosome 21 encodes a protein kinase presumed to be involved in the pathogenesis of mental retardation in Down's syndrome. Here we describe a highly similar homolog, DYRK1B, which is, in contrast to DYRK1A, predominately expressed in muscle and testis. The human DYRK1B gene was mapped to chromosome 19 (19q12-13.11) by radiation hybrid analysis. The amino acid sequences of DYRK1A and DYRK1B are 84% identical in the N-terminus and the catalytic domain but show no extended sequence similarity in the C-terminal region. DYRK1B contains all motifs characteristic for the DYRK family of protein kinases. In addition, the sequence comprises a bipartite nuclear localization motif. A green fluorescent protein (GFP) fusion protein of DYRK1B was found mainly in the nucleus of transfected COS-7 cells. These data suggest that DYRK1B is a muscle- and testis-specific isoform of DYRK1A and is involved in the regulation of nuclear functions. Copyright 1999 Academic Press. |
