| First Author | Bachus H | Year | 2019 |
| Journal | Immunity | Volume | 50 |
| Issue | 1 | Pages | 225-240.e4 |
| PubMed ID | 30635238 | Mgi Jnum | J:282528 |
| Mgi Id | MGI:6381169 | Doi | 10.1016/j.immuni.2018.11.012 |
| Citation | Bachus H, et al. (2019) Impaired Tumor-Necrosis-Factor-alpha-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants. Immunity 50(1):225-240.e4 |
| abstractText | Infants have a higher risk of developing allergic asthma than adults. However, the underlying mechanism remains unknown. We show here that sensitization of mice with house-dust mites (HDMs) in the presence of low-dose lipopolysaccharide (LPS) prevented T helper 2 (Th2) cell allergic responses in adult, but not infant, mice. Mechanistically, adult CD11b(+) migratory dendritic cells (mDCs) upregulated the transcription factor T-bet in response to tumor necrosis factor-alpha (TNF-alpha), which was rapidly induced after HDM + LPS sensitization. Consequently, adult CD11b(+) mDCs produced interleukin-12 (IL-12), which prevented Th2 cell development by promoting T-bet upregulation in responding T cells. Conversely, infants failed to induce TNF-alpha after HDM + LPS sensitization. Therefore, CD11b(+) mDCs failed to upregulate T-bet and did not secrete IL-12 and Th2 cell responses normally developed in infant mice. Thus, the availability of TNF-alpha dictates the ability of CD11b(+) mDCs to suppress allergic Th2-cell responses upon dose-dependent endotoxin sensitization and is a key mediator governing susceptibility to allergic airway inflammation in infant mice. |
