| First Author | Wilson EB | Year | 2013 |
| Journal | Science | Volume | 340 |
| Issue | 6129 | Pages | 202-7 |
| PubMed ID | 23580528 | Mgi Jnum | J:195487 |
| Mgi Id | MGI:5484680 | Doi | 10.1126/science.1235208 |
| Citation | Wilson EB, et al. (2013) Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science 340(6129):202-7 |
| abstractText | Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is associated with hyperimmune activation and disease progression in persistent infections. We demonstrated in mice that blockade of IFN-I signaling diminished chronic immune activation and immune suppression, restored lymphoid tissue architecture, and increased immune parameters associated with control of virus replication, ultimately facilitating clearance of the persistent infection. The accelerated control of persistent infection induced by blocking IFN-I signaling required CD4 T cells and was associated with enhanced IFN-gamma production. Thus, we demonstrated that interfering with chronic IFN-I signaling during persistent infection redirects the immune environment to enable control of infection. |
