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Protein Coding Gene : Hspa2 heat shock protein 2

Primary Identifier  MGI:96243 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  15512
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables glycolipid binding activity. Involved in spermatogenesis. Acts upstream of or within several processes, including male meiosis I; positive regulation of G2/M transition of mitotic cell cycle; and synaptonemal complex disassembly. Located in cell surface; meiotic spindle; and nucleus. Part of CatSper complex. Is expressed in several structures, including 2-cell stage embryo; alimentary system; ganglia; medulla oblongata basal plate; and submandibular gland primordium. Orthologous to human HSPA2 (heat shock protein family A (Hsp70) member 2).
PHENOTYPE: Homozygotes for a targeted null mutation exhibit male sterility associated with lack of postmeiotic germ cells and markedly increased frequency of spermatocyte apoptosis. [provided by MGI curators]
  • synonyms:
  • 70kDa,
  • MGD-MRK-10959,
  • heat shock protein 2,
  • MGD-MRK-19433,
  • Hspa2,
  • heat shock protein, 70 kDa 2,
  • Hsp70-2

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

12 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

1 Driver For