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Protein Coding Gene : Hspa9 heat shock protein 9
Primary Identifier  MGI:96245 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  15526
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables enzyme binding activity. Involved in iron-sulfur cluster assembly; negative regulation of hematopoietic stem cell differentiation; and negative regulation of hemopoiesis. Acts upstream of or within protein export from nucleus. Located in mitochondrial matrix. Is expressed in blastocyst-stage conceptus; early embryo; germ cell of gonad; heart; and liver. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete embryonic lethality while heterozygotes display decreased pre-B cell number. [provided by MGI curators]
  • synonyms:
  • mthsp70,
  • Hsp74a,
  • heat shock protein, 74 kDa,
  • MGI:1345461,
  • Hspa9a,
  • mortalin,
  • mot-2,
  • Hsp74,
  • heat shock protein 9,
  • C3H-specific antigen,
  • GRP75,
  • PBP74,
  • heat shock protein 9A,
  • Hspa9,
  • heat shock protein cognate 74,
  • CSA,
  • Hsc74,
  • MGD-MRK-10961
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