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Protein Coding Gene : C3 complement component 3

Primary Identifier  MGI:88227 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  12266
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable C5L2 anaphylatoxin chemotactic receptor binding activity and lipid binding activity. Involved in several processes, including nervous system development; positive regulation of endocytosis; and positive regulation of immune response. Acts upstream of or within several processes, including complement-dependent cytotoxicity; oviduct epithelium development; and positive regulation of immune response. Located in cell surface and extracellular space. Part of protein-containing complex. Is expressed in several structures, including adipose tissue; cerebral cortex; extraembryonic component; hemolymphoid system; and liver. Used to study complement component 3 deficiency. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3).
PHENOTYPE: Homozygous mutant mice exhibit abnormal immune responses, including increased mortality upon bacterial infection and decreased inflammatory response. [provided by MGI curators]
  • synonyms:
  • MGI:2146809,
  • complement component 3,
  • expressed sequence AI255234,
  • MGD-MRK-1700,
  • complement factor 3,
  • Plp,
  • acylation stimulating protein,
  • AI255234,
  • C3

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

21 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For