Primary Identifier | MGI:7507066 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Cfi |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Proline codon 467 (CCC) in exon 12 was changed to serine (TCC) (p.P467S) using sgRNAs and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human p.P447S mutation associated with C3 glomerulonephritis (C3GN). |