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Allele : Cfi<em2Jiwe> complement component factor i; endonuclease-mediated mutation 2, Jiqiu Wen

Primary Identifier  MGI:7507066 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Cfi
Is Recombinase  false Is Wild Type  false
molecularNote  Proline codon 467 (CCC) in exon 12 was changed to serine (TCC) (p.P467S) using sgRNAs and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human p.P447S mutation associated with C3 glomerulonephritis (C3GN).
  • mutations:
  • Single point mutation
  • synonyms:
  • CFI-P467S,
  • CFI-P467S
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories

Trail: Allele