Primary Identifier | MGI:1921367 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 74117 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Predicted to enable ATPase binding activity and actin binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Acts upstream of or within several processes, including cellular response to type II interferon; meiotic chromosome movement towards spindle pole; and meiotic cytokinesis. Located in brush border; cell-cell junction; and lamellipodium. Is expressed in several structures, including alimentary system; cerebral cortex; cochlea; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to human ACTR3 (actin related protein 3). PHENOTYPE: Mice homozygous for a null allele die prior to E4.5 and exhibit abnormal embryogenesis. [provided by MGI curators] |