| First Author | Krishnan S | Year | 2018 |
| Journal | Proc Natl Acad Sci U S A | Volume | 115 |
| Issue | 42 | Pages | 10738-10743 |
| PubMed ID | 30279177 | Mgi Jnum | J:266314 |
| Mgi Id | MGI:6209168 | Doi | 10.1073/pnas.1802320115 |
| Citation | Krishnan S, et al. (2018) Amphiregulin-producing gammadelta T cells are vital for safeguarding oral barrier immune homeostasis. Proc Natl Acad Sci U S A 115(42):10738-10743 |
| abstractText | gammadelta T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how these cells contribute to homeostasis at the gingiva, a key oral barrier and site of the common chronic inflammatory disease periodontitis, has not been explored. Here we demonstrate that the gingiva is policed by gammadelta T cells with a T cell receptor (TCR) repertoire that diversifies during development. Gingival gammadelta T cells accumulated rapidly after birth in response to barrier damage, and strikingly, their absence resulted in enhanced pathology in murine models of the oral inflammatory disease periodontitis. Alterations in bacterial communities could not account for the increased disease severity seen in gammadelta T cell-deficient mice. Instead, gingival gammadelta T cells produced the wound healing associated cytokine amphiregulin, administration of which rescued the elevated oral pathology of tcrdelta (-/-) mice. Collectively, our results identify gammadelta T cells as critical constituents of the immuno-surveillance network that safeguard gingival tissue homeostasis. |
