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Protein Domain : Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

Primary Identifier  IPR039485 Type  Family
Short Name  ALG12
description  N-linked glycosylation in eukaryotes requires the assembly of lipid-linkedoligosaccharide (LLO) precursor Glc3Man9GlcNAc2-pyrophosphate-dolichol (Glc3Man9Gn2-PDol). Addition of sugars to LLO is carried out sequentially by a serie of asparagine-linked glycosylation (Alg) glycosyltransferases []. ALG12 adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man7GlcNAc2). Deficiency of ALG12 results in glycosylation disorder type lG [, ].
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4 Protein Domain Regions

Trail: ProteinDomain




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