| Primary Identifier | IPR042123 | Type | Family |
| Short Name | Zip3/RNF212-like |
| description | This entry represents budding yeast Zip3 (also known as Cst9) and its homologues including Vilya/Nenya/narya from Drosophila melanogaster, RNF212/RNF212B from animals and Zip homologous proteins 1, 2, 3 and 4 from Caenorhabditis elegans. In budding yeasts, Zip3 is a SUMO E3 ligase and a component of the synapsis initiation complex (SIC) required for synaptonemal complex formation. Zip3 possesses a C3H2C3 RING finger motif, which is required for its E3 SUMO ligase activity in vitro [].The synaptonemal complex (SC) is a proteinaceous complex that apparently mediates synapsis between homologous chromosomes during meiotic prophase []. A number of chromosomal crossover factors and DNA damage repair components have been found to associate with both synaptonemal complexes and multiple synaptonemal complexes (polycomplexes). These include Zip3 (Cst9) from budding yeast, which localizes throughout the body of polycomplexes []. The presence of several Zip3-related proteins within the same organism, for instance the mammalian RNF212 ortholog (RNF212B), expands recombination control by E3-ligase activities []. Mouse RNF212 acts as a regulator of crossing-over during meiosis [].The Caenorhabditis elegans genome encodes at least four RING finger E3 ligase proteins, ZHP-1, ZHP-2, ZHP-3 and ZHP-4 that act together to promote a spatio-temporal accumulation of pro-crossover factors [].Drosophila melanogaster contain three Zip3-related proteins Vilya, Nenya and Narya which function in the formation of meiotic DNA DSBs and in the process of crossing over []. |
