| Primary Identifier | MGI:1922997 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 75747 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in several processes, including TORC2 signaling; regulation of signal transduction; and response to insulin. Acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Part of TORC2 complex. Is expressed in brain; cortical plate; and embryo. Orthologous to human SESN3 (sestrin 3). PHENOTYPE: When fed a high fat diet, mice homozygous for a gene trap allele exhibit impaired glucose tolerance, insulin resistance, reduced hepatic glucose production, impaired adipocyte glucose uptake, increased hepatic steatosis, and decreased mitochondria in the liver. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
