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Protein Coding Gene : Pias3 protein inhibitor of activated STAT 3

Primary Identifier  MGI:1913126 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  229615
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables SUMO transferase activity. Acts upstream of or within several processes, including negative regulation of macromolecule biosynthetic process; negative regulation of osteoclast differentiation; and protein sumoylation. Located in cytoplasm and nucleus. Is expressed in several structures, including blastocyst; central nervous system; eye; genitourinary system; and maxillary process. Orthologous to human PIAS3 (protein inhibitor of activated STAT 3).
PHENOTYPE: Double KO mice display a retinal phenotype reduced M-cone response at P21 and reduced S-cone and rod responses from 7 months. [provided by MGI curators]
  • synonyms:
  • Pias3L,
  • Pias3,
  • protein inhibitor of activated STAT 3

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

13 Pathways

2 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

1 Driver For