| First Author | Hamada H | Year | 2002 |
| Journal | Nat Rev Genet | Volume | 3 |
| Issue | 2 | Pages | 103-13 |
| PubMed ID | 11836504 | Mgi Jnum | J:74735 |
| Mgi Id | MGI:2159042 | Doi | 10.1038/nrg732 |
| Citation | Hamada H, et al. (2002) Establishment of vertebrate left-right asymmetry. Nat Rev Genet 3(2):103-13 |
| abstractText | The generation of morphological, such as left-right, asymmetry during development is an integral part of the establishment of a body plan. Until recently, the molecular basis of left-right asymmetry was a mystery, but studies indicate that Nodal and the Lefty proteins, transforming growth factor-beta-related molecules, have a central role in generating asymmetric signals. Although the initial mechanism of symmetry breaking remains unknown, developmental biologists are beginning to analyse the pathway that leads to left-right asymmetry establishment and maintenance. |
