| First Author | Doherty TM | Year | 1998 |
| Journal | Infect Immun | Volume | 66 |
| Issue | 9 | Pages | 4553-6 |
| PubMed ID | 9712819 | Mgi Jnum | J:49414 |
| Mgi Id | MGI:1277459 | Doi | 10.1128/iai.66.9.4553-4556.1998 |
| Citation | Doherty TM, et al. (1998) Paclitaxel (Taxol)-induced killing of Leishmania major in murine macrophages. Infect Immun 66(9):4553-6 |
| abstractText | The antitumor drug paclitaxel (Taxol) has been demonstrated to be a lipopolysaccharide mimetic in murine macrophages. In this study, the capacity of paclitaxel to activate macrophages to become microbicidal for Leishmania major was examined. Paclitaxel and gamma interferon synergized to kill intracellular L. major in Lpsn, but not Lpsd, macrophages by a nitric oxide (NO.)-dependent mechanism. |
