Primary Identifier | MGI:4368010 | Allele Type | Targeted |
Attribute String | Inserted expressed sequence | Gene | Ilk |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Serine acid codon 343 (TCT) in exon 11 was changed to aspartic acid (p.S343D) and a loxP site flanked neomycin resistance gene cassette was inserted into the 3' UTR in exon 13. The neo cassette was removed through subsequent Cre-mediated recombination. This substitution produces a hyperactive product. |