| First Author | Montanez E | Year | 2008 |
| Journal | Genes Dev | Volume | 22 |
| Issue | 10 | Pages | 1325-30 |
| PubMed ID | 18483218 | Mgi Jnum | J:134768 |
| Mgi Id | MGI:3789779 | Doi | 10.1101/gad.469408 |
| Citation | Montanez E, et al. (2008) Kindlin-2 controls bidirectional signaling of integrins. Genes Dev 22(10):1325-30 |
| abstractText | Control of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-implantation lethality caused by severe detachment of the endoderm and epiblast from the basement membrane. We found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindlin-2 is required for talin-induced integrin activation. Furthermore, we demonstrate that Kindlin-2 is required for integrin outside-in signaling to enable firm adhesion and spreading. Our findings provide evidence that Kindlin-2 is a novel and essential element of bidirectional integrin signaling. |
