Type | disruption phenotype | Description | Knockout mice are viable and exhibit no discernible phenotypes in the overall liver architecture and hepatocytes (PubMed:30374053, PubMed:32380568). However, they display impaired hepatic regeneration with reduced Wnt signaling (PubMed:32380568). Knockout mice also show a suppression of intestinal tumorigenesis (PubMed:30374053). |