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Publication : A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide.

First Author  Morrison GM Year  1999
Journal  FEBS Lett Volume  442
Issue  1 Pages  112-6
PubMed ID  9923615 Mgi Jnum  J:52008
Mgi Id  MGI:1327697 Doi  10.1016/s0014-5793(98)01630-5
Citation  Morrison GM, et al. (1999) A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide. FEBS Lett 442(1):112-6
abstractText  Studies have shown that beta defensins are present in the human airways and may be relevant to the pathogenesis of cystic fibrosis lung disease. Here we report the identification of a novel mouse gene, Defb2, which shows sequence similarity to previously described mouse and human airway beta defensins. Defb2 does not appear to be expressed in the airways of untreated mice but it is upregulated in response to lipopolysaccharide. The induced expression of this gene by an inflammatory stimulus strongly suggests that this defensin contributes to host defence at the mucosal surface of the airways.
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