| First Author | Kurohara K | Year | 2000 |
| Journal | Biochem Biophys Res Commun | Volume | 270 |
| Issue | 2 | Pages | 522-7 |
| PubMed ID | 10753657 | Mgi Jnum | J:61574 |
| Mgi Id | MGI:1355180 | Doi | 10.1006/bbrc.2000.2429 |
| Citation | Kurohara K, et al. (2000) Meltrin beta (ADAM19) gene: cloning, mapping, and analysis of the regulatory region. Biochem Biophys Res Commun 270(2):522-7 |
| abstractText | Meltrin beta (ADAM19) is a member of the metalloprotease-disintegrin family. We report here chromosomal mapping of the mouse and rat meltrin beta genes and cloning and analysis of the mouse upstream regulatory regions. The meltrin beta transcript shows a spatially and temporally restricted expression pattern during morphogenesis, indicating that the actions of this membrane-bound protease are regulated, at least in part, at the transcriptional level. Analysis of the promoter revealed positive and negative regulatory regions upstream of the gene. The former includes a GC-box that appears to be a critical cis-element for activation of the promoter in muscle cells. Copyright 2000 Academic Press. |
