|  Help  |  About  |  Contact Us

Protein Coding Gene : Pdpk1 3-phosphoinositide dependent protein kinase 1

Primary Identifier  MGI:1338068 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  18607
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables 3-phosphoinositide-dependent protein kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of cardiac muscle cell apoptotic process; and type B pancreatic cell development. Acts upstream of or within hyperosmotic response. Located in cytoplasmic vesicle and postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; gonad; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1).
PHENOTYPE: Homozygous mutant mice exhibit embryogenesis defects, impaired forebrain development, and die by mid gestation. Cardiac muscle-specific conditional mutants exhibit thin ventricular walls and die of heart failure. [provided by MGI curators]
  • synonyms:
  • 3-phosphoinositide dependent protein kinase 1,
  • Pdpk1,
  • Pdk1,
  • Pkb kinase

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

57 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For