| First Author | Zhu M | Year | 2020 |
| Journal | Int Immunopharmacol | Volume | 81 |
| Pages | 106034 | PubMed ID | 31786099 |
| Mgi Jnum | J:301163 | Mgi Id | MGI:6502926 |
| Doi | 10.1016/j.intimp.2019.106034 | Citation | Zhu M, et al. (2020) The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice. Int Immunopharmacol 81:106034 |
| abstractText | GPR174 plays a crucial role in immune responses, but the role of GPR174 in the pathological progress of sepsis remains incompletely understood. In this study, we generated a sepsis model by cecal ligation and puncture (CLP) to investigate the role of GPR174 in regulating functions and underlying mechanism of marginal zone B (MZ B) cells in sepsis. We found that in Gpr174 deficient mice, the number of splenic MZ B cells was increased. Moreover, Gpr174(-/-) MZ B cells exhibited an enhanced response to LPS stimulation in vitro. By using the CLP-induced sepsis model, we demonstrated that the increased MZ B cells attenuated early inflammatory responses during sepsis. RNA sequencing results revealed that the expression of c-fos in splenic B lymphocytes was upregulated in Gpr174 deficient mice. However, the protective role of increased MZ B cells in Gpr174 deficient mice was weakened by a c-fos-specific inhibitor. Collectively, these findings suggested that GPR174 plays an immunomodulatory role in early immune responses during sepsis through the regulation of MZ B cells. |
