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Publication : Evidence that nucleotide sequence identity is a requirement for meiotic crossing over within the mouse Eb recombinational hot spot.

First Author  Sant'Angelo DB Year  1992
Journal  Genomics Volume  13
Issue  4 Pages  1334-6
PubMed ID  1505968 Mgi Jnum  J:1732
Mgi Id  MGI:50258 Doi  10.1016/0888-7543(92)90061-v
Citation  Sant'Angelo DB, et al. (1992) Evidence that nucleotide sequence identity is a requirement for meiotic crossing over within the mouse Eb recombinational hot spot. Genomics 13(4):1334-6
abstractText  Meiotic recombination in the mouse is sometimes restricted to specific chromosomal sites. For example, when recombinants within the I region of the mouse major histocompatibility complex (MHC) are examined, the breakpoints between standard alleles can usually be mapped to the Eb gene. DNA sequence analysis of five cases of meiotic crossing over associated with this gene suggests that the recombinational hot spot may be confined to large regions of nucleotide identity located within the second intron of the Eb gene.
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