| First Author | Nishimura T | Year | 2000 |
| Journal | Biochim Biophys Acta | Volume | 1492 |
| Issue | 1 | Pages | 203-6 |
| PubMed ID | 10858549 | Mgi Jnum | J:63008 |
| Mgi Id | MGI:1860324 | Doi | 10.1016/s0167-4781(00)00067-1 |
| Citation | Nishimura T, et al. (2000) Identification of a novel FGF, FGF-21, preferentially expressed in the liver(1). Biochim Biophys Acta 1492(1):203-6 |
| abstractText | We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus ( approximately 30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical ( approximately 75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar ( approximately 35% amino acid identity) to FGF-19. |
