| First Author | Trampont PC | Year | 2010 |
| Journal | Nat Immunol | Volume | 11 |
| Issue | 2 | Pages | 162-70 |
| PubMed ID | 20010845 | Mgi Jnum | J:158414 |
| Mgi Id | MGI:4438706 | Doi | 10.1038/ni.1830 |
| Citation | Trampont PC, et al. (2010) CXCR4 acts as a costimulator during thymic beta-selection. Nat Immunol 11(2):162-70 |
| abstractText | Passage through the beta-selection developmental checkpoint requires productive rearrangement of segments of the T cell antigen receptor-beta gene (Tcrb) and formation of a pre-TCR on the surface of CD4(-)CD8(-) thymocytes. How other receptors influence betabeta-selection is less well understood. Here we define a new role for the chemokine receptor CXCR4 during T cell development. CXCR4 functionally associated with the pre-TCR and influenced beta-selection by regulating the steady-state localization of immature thymocytes in thymic subregions, by facilitating optimal pre-TCR-induced survival signals, and by promoting thymocyte proliferation. We also characterize functionally relevant signaling molecules downstream of CXCR4 and the pre-TCR in thymocytes. Our data designate CXCR4 as a costimulator of the pre-TCR during beta-selection. |
