First Author | Huang RP | Year | 1994 |
Journal | Biochem Biophys Res Commun | Volume | 200 |
Issue | 3 | Pages | 1271-6 |
PubMed ID | 8185575 | Mgi Jnum | J:18073 |
Mgi Id | MGI:66092 | Doi | 10.1006/bbrc.1994.1588 |
Citation | Huang RP, et al. (1994) The phosphorylated forms of the transcription factor, Egr-1, bind to DNA more efficiently than non-phosphorylated. Biochem Biophys Res Commun 200(3):1271-6 |
abstractText | The transcription factor, Early growth response-1, Egr-1, occurs in several forms differing in length due to three alternate translation start sites (1). Egr-1 has also been reported to be phosphorylated although a role for this modification is unknown. Using dephosphorylation and hyperphosphorylation studies, we show here that phosphorylated Egr-1 is much more efficiently bound to its DNA binding element (GCE) and binds in a dose-dependent fashion. Egr-1 plays complex roles in growth regulation and we suggest that alternate forms of phosphorylated Egr-1 may account for this. |