| First Author | Cui C | Year | 2021 |
| Journal | Cell | Volume | 184 |
| Issue | 25 | Pages | 6101-6118.e13 |
| PubMed ID | 34852236 | Mgi Jnum | J:316085 |
| Mgi Id | MGI:6833923 | Doi | 10.1016/j.cell.2021.11.007 |
| Citation | Cui C, et al. (2021) Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses. Cell 184(25):6101-6118.e13 |
| abstractText | CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We found enrichment of TFH cell transcriptional signature correlates with GC B cell signature and with prolonged survival in individuals with lung adenocarcinoma (LUAD). We further developed a murine LUAD model in which tumor cells express B cell- and T cell-recognized neoantigens. Interactions between tumor-specific TFH and GC B cells, as well as interleukin (IL)-21 primarily produced by TFH cells, are necessary for tumor control and effector CD8 T cell function. Development of TFH cells requires B cells and B cell-recognized neoantigens. Thus, tumor neoantigens can regulate the fate of tumor-specific CD4 T cells by facilitating their interactions with tumor-specific B cells, which in turn promote anti-tumor immunity by enhancing CD8 T cell effector functions. |
