| Primary Identifier | MGI:1316649 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20698 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables D-erythro-sphingosine kinase activity; acetyltransferase activity; and sphinganine kinase activity. Involved in several processes, including negative regulation of ceramide biosynthetic process; regulation of microglial cell activation; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; positive regulation of mitotic nuclear division; and sphingolipid mediated signaling pathway. Located in endocytic vesicle; nucleus; and presynapse. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SPHK1 (sphingosine kinase 1). PHENOTYPE: Homozygous null mice are viable, fertile, and without any obvious abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
