| Primary Identifier | IPR000969 | Type | Family |
| Short Name | SSRP1/POB3 |
| description | FACT (facilitates chromatin transactions) is a general chromatin factor that acts to reorganise nucleosomes. It is a complex that consists of several subunits [, , , ]. This entry represents the FACT complex subunits POB3, which is present in yeast, and the related SSRP1, found in higher eukaryotes. SSRP1 binds specifically to DNA modified with the anti-cancer drug cisplatin. It contains a high mobility group (HMG) box domain () that probably constitutes the structure recognition element for cisplatin-modified DNA, the probable recognition motif being the local duplex unwinding and bending that occurs on formation of intra-strand cross-links [, , ]. |
