Primary Identifier | MGI:107683 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 18846 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables semaphorin receptor activity. Involved in nervous system development; positive regulation of cytoskeleton organization; and semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including hippocampus development; negative regulation of axon extension involved in axon guidance; and neuron development. Predicted to be located in membrane. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Orthologous to human PLXNA3 (plexin A3). PHENOTYPE: Mice homozygous for disruptions in this gene possess misdirected axons in the hippocampus. They are, otherwise, indistinguishable from wild-type mice. [provided by MGI curators] |