| First Author | Takaki S | Year | 2000 |
| Journal | Immunity | Volume | 13 |
| Issue | 5 | Pages | 599-609 |
| PubMed ID | 11114373 | Mgi Jnum | J:66032 |
| Mgi Id | MGI:1927743 | Doi | 10.1016/s1074-7613(00)00060-1 |
| Citation | Takaki S, et al. (2000) Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity 13(5):599-609 |
| abstractText | Lnk is an SH2 domain-containing adaptor protein expressed preferentially in lymphocytes. To illuminate the importance of Lnk, we generated lnk(-/-) mice. Whereas T cell development was unaffected, pre-B and immature B cells accumulated in the spleens. In the bone marrow, B-lineage cells were proportionately increased, reflecting enhanced production of pro-B cells that resulted in part from hypersensitivity of precursors to SCF, the ligand for c-kit. Hence, Lnk ordinarily acts to regulate B cell production. Further characterization of lnk(-/-) mice also revealed that full-length Lnk is a 68 kDa protein containing a conserved proline-rich region and a PH domain. Lnk is a representative of a multigene adaptor protein family whose members act, by analogy with Lnk, to modulate intracellular signaling. |
