| First Author | Topol L | Year | 2003 |
| Journal | J Cell Biol | Volume | 162 |
| Issue | 5 | Pages | 899-908 |
| PubMed ID | 12952940 | Mgi Jnum | J:85368 |
| Mgi Id | MGI:2674191 | Doi | 10.1083/jcb.200303158 |
| Citation | Topol L, et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol 162(5):899-908 |
| abstractText | Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing beta-catenin in many biological systems. We have uncovered a new noncanonical pathway through which Wnt-5a antagonizes the canonical Wnt pathway by promoting the degradation of beta-catenin. This pathway is Siah2 and APC dependent, but GSK-3 and beta-TrCP independent. Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation. |
