| First Author | Montecino-Rodriguez E | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 3 | Pages | 293-301 |
| PubMed ID | 16429139 | Mgi Jnum | J:112481 |
| Mgi Id | MGI:3656405 | Doi | 10.1038/ni1301 |
| Citation | Montecino-Rodriguez E, et al. (2006) Identification of a B-1 B cell-specified progenitor. Nat Immunol 7(3):293-301 |
| abstractText | The B-1 subpopulation of B lymphocytes differs phenotypically and functionally from conventional B-2 B cells. B-1 B cells are proposed to derive from a distinct progenitor, but such a population has not been isolated. Here we identify and characterize a B-1 B cell progenitor whose numbers peaked in fetal bone marrow but were less abundant in postnatal bone marrow. These Lin(-)CD45R(lo-neg)CD19(+) cells responded to thymic stromal lymphopoietin and 'preferentially' reconstituted functional sIgM(hi)CD11b(+)CD5(lo-neg) B-1 B cells, but not sIgM(+)CD11b(-) B-2 B cells, in vivo. These data indicate that the CD45R(lo-neg)CD19(+) population includes B-1 B cell-specified progenitors and support models proposing distinct developmental pathways for B-1 B cells. |
