| First Author | Katz JD | Year | 1995 |
| Journal | Science | Volume | 268 |
| Issue | 5214 | Pages | 1185-8 |
| PubMed ID | 7761837 | Mgi Jnum | J:109915 |
| Mgi Id | MGI:3630091 | Doi | 10.1126/science.7761837 |
| Citation | Katz JD, et al. (1995) T helper cell subsets in insulin-dependent diabetes. Science 268(5214):1185-8 |
| abstractText | It has been proposed that the development of insulin-dependent diabetes is controlled by the T helper 1 (TH1) versus TH2 phenotype of autoreactive TH cells: TH1 cells would promote diabetes, whereas TH2 cells would actually protect from disease. This proposition was tested by establishing cultures of TH1 and TH2 cells that express an identical diabetogenic T cell receptor and comparing their ability to initiate disease in neonatal nonobese diabetic mice. TH1-like cells actively promoted diabetes; TH2-like cells invaded the islets but did not provoke disease--neither did they provide substantial protection. |
