| Primary Identifier | MGI:1201791 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 12702 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables miRNA binding activity and phosphotyrosine residue binding activity. Involved in cellular response to interleukin-17. Acts upstream of or within several processes, including branching involved in labyrinthine layer morphogenesis; cellular response to leukemia inhibitory factor; and negative regulation of insulin receptor signaling pathway. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasmic side of plasma membrane. Is expressed in several structures, including extraembryonic component; liver; placenta; retina; and spleen. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). PHENOTYPE: Mice homozygous for mutations cause impairment if gene expression show immunological and hematopoetic abnormalities. Complete gene disruption causes lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
