| Primary Identifier | MGI:1924859 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 77609 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in cilium movement; outer dynein arm assembly; and regulation of cilium assembly. Acts upstream of or within several processes, including determination of heart left/right asymmetry; epithelial cilium movement involved in extracellular fluid movement; and flagellated sperm motility. Located in centriole and ciliary basal body. Is expressed in node and trachea. Used to study Kartagener syndrome and primary ciliary dyskinesia 30. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3). PHENOTYPE: Mico homozygous for an ENU-induced allele exhibit dextrocardia associated with situs inversus totalis and hypoplastic spleen, adrenal anomalies and immotile/dyskinetic tracheal airway cilia. Mice homozygous for a conditional allele activated ubiquitously in adults exhibit reduced sperm number and motility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
